Phenibut 90 x 250mg Capsules

Beta-phenyl-gamma-aminobutyric acid, better known as Phenibut or less commonly Fenibut or Phenybut, is natural derivative of the inhibitory neurotransmitter GABA (Gamma amino butyric acid). Sold as a dietary supplement in the US while in Russia sold as a neuropsychotropic drug that is capable of passing the blood-brain barrier. Phenibut is cited as a nootropic for its ability to improve neurological functions. It was discovered in Russia in the 1960's, and has since been used there to treat a wide range of ailments including anxiety and insomnia.

The name Phenibut, along with many of the other names for the compound, comes directly from the chemical name for the compound, beta-phenyl-gamma-aminobutyric acid.

[edit] Contraindications and side effects

Phenibut can have unpleasant dose-dependent withdrawal symptoms. Withdrawal symptoms can include acute anxiety and insomnia that can last for up to two weeks afterwards. Withdrawal symptoms, however, are almost always associated with cessation after prolonged usage. Tolerance to phenibut can develop quite rapidly.^{[citation needed]}

Phenibut should not be mixed with alcohol, sedatives or prescription medication without consulting with a healthcare professional.

Persons on MAO inhibitors or epilepsy medications like carbamazepine or oxcarbazepine should consult with their psychiatrist/physician prior to supplementation with phenibut. Clinical research has demonstrated that phenibut can potentiate or inhibit the function of some epilepsy medications.^{[citation needed]}

[edit] Doses

Commonly recommended doses are 250-3,000 mg as needed or daily with weekly cycling off during weekends.

[edit] Pharmacology

Structurally, phenibut is similar to baclofen and phenethylamine, although it is not considered a phenethylamine. Phenibut is a GABA_B receptor agonist, with slight activity at GABA_A receptors. The pharmacological effects of phenibut are similar to baclofen, but less potent on a per milligram dosage.^{[citation needed]}

Phenibut is a phenylethylamine antagonist and thus reduces the effects of phenylethylamine and other compounds that raise phenylethylamine levels.

Phenibut was developed by The Volgograd State Medical University. Phenibut is a daytime anxiolytic drug which does not exert a sedative effect. Therefore it is particularly useful for those people who need to exert high concentration during the daytime, especially during driving.

[edit] References

• Shulgina GI (1986). "On neurotransmitter mechanisms of reinforcement and internal inhibition". Pavlov J Biol Sci 21 (4): 129–40. PMID 2431377. 

• Chojnacka-Wójcik E, Hano J, Sieroslawska J, Sypniewska M (1975). "Pharmacological properties of gamma-animobutyric acid and it derivatives. IV. Aryl gaba derivatives and their respective lactams". Arch. Immunol. Ther. Exp. (Warsz.) 23 (6): 733–46. PMID 1241266. 

• Lapin I (2001). "Phenibut (beta-phenyl-GABA): a tranquilizer and nootropic drug". CNS Drug Rev 7 (4): 471–81. PMID 11830761. 

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• Talalaenko AN, Pankrat'ev DV, Goncharenko NV (March 2003). "Neurochemical characteristics of the ventromedial hypothalamus in mediating the antiaversive effects of anxiolytics in different models of anxiety". Neurosci. Behav. Physiol. 33 (3): 255–61. PMID 12762592. http://www.kluweronline.com/art.pdf?issn=0097-0549&volume=33&page=255. 

• Talalaenko AN, Pankrat'ev DV, Goncharenko NV (2002). "[Monoaminergic and aminoacidergic mechanisms of the posterior hypothalamus in realization of the antiaversive effects of anxiosedative and anxioselective agents in various anxiety models]" (in Russian). Eksp Klin Farmakol 65 (5): 22–6. PMID 12596508. 

• Talalaenko AN, Pankrat'ev DV, Goncharenko NV (September 2001). "[Neurochemical characteristics of the ventromedial hypothalamus and anti-aversive effects of anxiolytic agents in various anxiety models]" (in Russian). Ross Fiziol Zh Im I M Sechenova 87 (9): 1217–26. PMID 11763535. 

• Kresiun VI (1984). "[Mg2+-ATPase activity of brain mitochondria fractions in chronic stress and its correction by psychotropic agents]" (in Russian). Ukr. Biokhim. Zh. 56 (6): 637–41. PMID 6151270.