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Description
PT-141 (Bremelanotide) Information
PT-141 is a new drug which has been developed to treat low sexual desire in women initially. Subsequently, it has been found to work very effectively for men as well.
What is Bremelanotide (PT-141)?
Bremelanotide (formerly bremelanotide (PT-141)) is the generic term for
a new medication for use in treating sexual dysfunction in men
(erectile dysfunction or impotence) as well as sexual dysfunction in
women (sexual arousal disorder). It is a synthetic aphrodisiac. Unlike
Viagra and other related medications, it does not act upon the vascular
system, but directly increases sexual desire.
Originally, the peptide Melanotan II that bremelanotide was developed
from was tested as a sunless tanning agent. In initial testing,
Melanotan II did induce tanning but additionally caused sexual arousal
and spontaneous erections as unexpected side effects in eight out of
the ten original male volunteer test subjects. In clinical studies,
bremelanotide has been shown to be effective in treating male sexual
and erectile dysfunction as well as female sexual dysfunction. It is
currently being tested by Palatin Technologies.
Bremelanotide is a cyclic hepta-peptide lactam analog of
alpha-melanocyte-stimulating hormone (alpha-MSH) that activates the
melanocortin receptors MC3-R and MC4-R in the central nervous system.
It has the amino acid sequence
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH or cyclo-[Nle4, Asp5,
D-Phe7, Lys10]alpha-MSH-(4-10). bremelanotide (PT-141) is a metabolite
of Melanotan II that lacks the C-terminal amide function. Its molecular
formula is C50H68N14O10 with a molecular weight of 1025.2.
In the United States it is currently in a Phase III clinical trial.
Are these nasal? Oral, Injectable?
The nasal route is recommended.
What's the dosing schedule...how much do I take?
1-2mg is the typical effective dose. Nasally, as little as 0.5mg can be used.
How is it stored?
The lyophilized powder (freeze dried state) can be stored in the
freezer or refrigerator. Once reconstituted (mixed with water) it will
be good for a month in the refrigerator before it begins to degrade.
Does this help give erections or just put you in the mood?
“With bremelanotide (PT-141), you feel good, not only sexually
aroused,” reported anonymous patient 007, a participant in a Phase 2
trial, “you feel younger and more energetic.” Said another patient: “It
helped the libido. So you have the urge and the desire. . . . You get
this humming feeling; you’re ready to take your pants off and go.” And
another: “Twice my wife and I had sex twice in one night. I came in [to
work] and I just raved about it: ‘Jesus, guys . . . 58 years old and
you don’t do that.’ ” Tales of pharmaceutically induced sexual prowess
among 58-year-olds are common enough in the age of the Little Blue
Pill, but they don’t typically involve quite so urgent a repertoire of
humming, throbbing, tingling, and double-dipping. Or as patient 128 put
it: “My wife knows. She can tell the difference between Viagra and
bremelanotide (PT-141).”
The precise mechanisms by which bremelanotide (PT-141) does its job
remain unclear, but the rough idea is this: Where Viagra acts on the
circulatory system, helping blood flow into the penis, bremelanotide
(PT-141) goes straight to the brain itself. And there it goes to work,
switching on the same neural circuitry that lights up when a person
actually, you know, wants to.
Basically this takes men back to middle school. You may find yourself
in a similar situation as you were in 8th grade science class with the
teacher bent over helping the student in front of you. It may be
necessary to do a “tuck up” if at the office…especially at the public
pool!
Women state that the sensation given from injecting bremelanotide
(PT-141) is like being in heat! One colleague in particular stated that
she didn’t know what was going on…but she had wanted “it” all day long
after dosing the night before.
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