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Aniracetam (1-(p-anisoyl)-2 pyrrolidinone; 1-(4 methoxybenzoyl)
2-pyrrolidinone) is a cognitive enhancer related to piracetam, but
approximately 5-10 times as potent. Clinical studies in the elderly
have found it to have nootropic, anxiety-reducing, and antidepressant
properties. Studies in many animal species, including monkeys, have
found that aniracetam improves cognition in both healthy adult animals
and animals impaired by a variety of drugs and conditions, and it
improves cognitive performance on some tests in which piracetam is
ineffective.
Aniracetam functions through multiple mechanisms,
including positive modulation of AMPA receptors and increasing
acetylcholine, dopamine, and serotonin release in some areas of the
brain. Like piracetam, it is virtually non-toxic and associated with
very few side effects. It may cause insomnia in some individuals if
taken close to bedtime. The effect after a single dose of aniracetam
peaks two hours after administration and reaches baseline by the six
hour point. Recommended dosage is 750-1500 mg daily, or lower if used
in conjunction with other nootropics.
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