Description
; previously known as amfebutamone,[1] Wellbutrin, Zyban) is an atypical antidepressant that acts as a norepinephrine and dopamine reuptake inhibitor, and nicotinic antagonist.[2][3] Bupropion belongs to the chemical class of aminoketones and is similar in structure to the stimulant cathinone, to the anorectic diethylpropion, and to phenethylamines in general.
Initially researched and marketed as an antidepressant, bupropion was subsequently found to be effective as a smoking cessation
aid. In 2006 it was the fourth-most prescribed antidepressant in the
United States retail market, with more than 21 million prescriptions.[4]
Bupropion lowers seizure threshold and its potential to cause seizures
was widely publicized. However, at the recommended dose the risk of
seizures is comparable to that observed for other antidepressants.
Bupropion is an effective antidepressant on its own but it is
particularly popular as an add-on medication in the cases of incomplete
response to the first-line SSRI
antidepressant. In contrast to many psychiatric drugs, including nearly
all antidepressants, bupropion does not cause weight gain or sexual dysfunction.
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